Twofold response. From a fictional point of view, those sound like powerful, evocative choices for Theme and Threat, and they would probably do a good job of driving a dark, brooding sort of game. My only criticism might be that they seem a bit generic, and could apply to almost any big city, anywhere, not necessarily New York, except for the use of New York's nickname "The Big Apple".
The from the point of view of a native New Yorker, I'm afraid (or rather happy) to say both Themes are horrifically out of date, by 30 or 40 years. New York's crime rate, relative to it's size, is quite low, there aren't a ton of homeless people, the poverty rate has gone way down, police relations are relatively civil, and the city government is famous for it's complexity, scope and occasional dysfunction, but not for corruption and apathy.
The city that you're describing sound more like New Orleans, Detroit, Baltimore, LA, maybe Miami, Philly, or DC. I hesitate to add Chicago to that list, since I bet the myths and the facts about Chi town are probably as mixed up as those about NYC.
The thing that's cool and scary about the real NYC is that it's a city of the world (arguably THE city of the world), and it can roll right over you crush you without noticing or caring. Also, it's target number one on the list of basically every terrorist group, foreign or domestic, on the planet. Also, a major center of world finance, and home of most of the asshats that caused the global financial meltdown. Also, the UN is here.
It's scary, but in a Summer court, "Look at all that freaking out of control growth!" sort of way, rather than a Winter Court, "Rotting corpse of a once great city" way.
As far as becoming prey, you're much less likely to lose your life than to lose you dream. The kind of predators that exist in NYC are more likely to consume the soul, and leave the body; an empty, corporate drone. And those are just the mundane predators that really exist, let alone the supernatural ones.
That bit about the competition between locations to be the next ACN is perfect, since NYC is where the powerful come to make deals that change the lives of people all over the world, for better or worse, so being the one ACN in NYC would be incredibly prestigious.
Having said that, hey, the themes you chose would totally work, and if you game group likes playing in that version of NYC, go nuts and have fun.