Sure, easy peasy. But, do you have any questions on your mind at this point. I think you'll get more out of this if you ask questions and we answer, rather than just getting an info dump, which may or may not help.
You say you're familiar with D&D, etc. but have never played them. So, I don't think comparing DFRPG to those games will help you much. Do you have any particular questions that we can help clear up? Do you understand how you would punch a guy, to use a simple example?
If you understand that much, I'd suggest reading the "What's on your Character Sheet" section on Page 17 and seeing if that makes sense to you. If so, I'd move to the Creating your Character and City Creations Chapters and see if those bring up any questions.