1. We have been told that Nicodemus has a very specific target in mind, ostensibly kept in the Labyrinth of Daedalus.  What is Nic trying to get his hands on and why?
Holy Grail (Chalice) and/or Denarian coins;
Location amended for updated hint: We now have a hint that prior to entering the NeverNevers highest security vault Nicodemus and friends must first break into Chicago's most secure vault.  I guess that it is the Federal Reserve Building in Chicago.  This would be the bank which Marcone utilizes to secure his belongings.  One must wonder what does he keep there.  Perhaps one item is Thorned Namshiel denarian aka Spiny Boy's coin.

2. Nicodemus apparently called in a marker from Mab to get Harry on the team.  Does he have a specific plan for using Harry or did Mab twist his request?  Which of Harry's capabilities will he admit to needing, and (given that this is Nicodemus after all), which abilities is he scheming for Harry to use?
Nicodemus either needs access to power from Winter and/or Soulfire in the attempt to break into the vault.  He may also need access to Demonreach island to access the underworld.  Nic hopes that Harry will kill some team members that have a Nemesis connection.  With Harry's brush with death, he is now a fulcrum for the underworld in addition to the Living.

3. Jim has mentioned that the book will be "Ocean's Eleven".  Who else did Nicodemus recruit?  How will they interact with Harry? Naagloshii, Shapeshifter, Denarians, Churchmice, BC Vampire.  Some will attempt to kill Harry.  One may assist him.  Most of the murder attempts will be in passing, trying to get Harry killed by protections on the vault, etc.

4. Harry's general method of operation is to call on his friends for help.  In this book, Harry is (initially) allowed one extra backup member on the crew.  Who will it be?  Which of Harry's other allies will "interfere" before the plot is over?  9/10/13 an interview was published that answers the first half of this question.  (edit:  Sort of)  Those that guessed what he said in that interview (at least partially) have been logged by the curators, but this will probably go down as some kind of extra credit or something, so keep Predictin!  (edit:  And things might not be binary simple...)-Serack
Well, we already know Harry is choosing Murphy.  I think Molly, Sarissa, Fix, Thomas, Mouse will assist Harry near the end.  Maybe we will even see Cat Sith again.

5. This is a Denarian book, so (unlike the last "end of the world" showdown), the Swords will almost certainly be present.  In fact, there have been various hints...  Which Sword wielders will appear in the next book and how will their interference/help affect the plot?
Sanya, Murphy, Daniel.  Team Heaven will win one with one of the Knights convincing a Host to give up their coin. 

6. Mab is apparently against Nicodemus succeeding in this heist.  In the Cold Days, we found that Mab had complex reasons for wanting Harry to kill Maeve.  What are Mab's reasons in this book?  Is it simple thwarting or is there something deeper?
Strike at Nicodemus for violating the Accords in Small Favor.  Assist Anduriel in getting rid of Nicodemus and/or obtaining another Host.

7. At the end of Cold Days, Harry needs to stay on the island to keep his growing headaches at bay.  The start of Skin Games implies that those headaches will need to be resolved by the end of the book.  Who or what is causing those headaches, and how will the whole thing get resolved by the end of the book?
A combination of primarily Lash but she is tainted with Outsider infection when she took the bullet for Harry.  Harry's continued use of Soulfire is empowering the Lash essence, helping it grow but also getting it to cause more harmful headaches et cetera.  She will find a home in a certain Nickle Harry finds placed somewhere in by Odin.

8.  One of the key components of the "Ocean's Eleven" movie is that there is a final twist/reveal.  Given that we've got Nicodemus, Harry, Mab, and potentially Hades (and who knows who else) all trying to get the better of each other, if there's one thing you can count on it's some sort of last minute quintuple-cross.  What will be the nature of the twist and how will it all fall out?
Harry fails.  Molly, Sarissa save the day.  Nicodemus will violate the agreement he made with Mab when she negotiated an explicit truce until such time that the mission is complete.  Mab will pitch in an assist.

9.  (Extra Credit) There are many WAG ("Wild A$$ Guess") theories on the boards, some crazier than others.  Write up to three WAG theories (or make up your own) you believe are correct that will be confirmed (or at least have evidence in favor of) in Skin Games.
1) Ferro banks at Hades vault.
2) Cerberus likes Harry (senses Mouse)
3) Underworld is using Harry to amputate Nemesis infection

10. (Extra Credit) This is that "free form" question where you can come up with anything else you think will be in this book.  Specific quotes Harry might say (will he actually quote Ocean's Eleven?  The movie will have come out already in Harry's timeline)? Tidbits about the White Council? The fate of Molly? Write down anything you want.  Note that whatever you write must be specifically mentioned or hinted at in Skin Games in order to be worth credit.
Merlin wants to carry out Doom on Harry, for Molly's abuse of the Laws.  WC concedes they can't bring Molly to justice but will try with Harry.  Molly and/or Mab might have a problem with that.
Harry promises Michael that he will save Molly from Winter Mantle at some point.

It wasn't a mortal that infected Cat Sith. We have yet to see a proven instance of a mortal being infected.

We don't know exactly who infected Cat Sith.  Harry believes it to be Sharkface and He is probably right.  But, it is also sensible that Harry's orders could be made in such a way as to place him in an unintended bind when it comes to the enemy.

Moral Absolutism is the ethical belief that there are absolute standards against which moral questions can be judged, and that certain actions are right or wrong,

Moral absolutism states that there is an Absolute standard.

Moral relativism simply holds that there are disagreements about morals and that there is no "right or wrong."

Moral relativism may be any of several philosophical positions concerned with the differences in moral judgments across different people and cultures. Descriptive moral relativism holds only that some people do in fact disagree about what is moral; meta-ethical moral relativism holds that in such disagreements, nobody is objectively right or wrong; and normative moral relativism holds that because nobody is right or wrong, we ought to tolerate the behavior of others even when we disagree about the morality of it.

Also, in order for something to be morally wrong there must be an absolute objective standard that makes it wrong.

In this case, Mab is the standard for what is or is not morally wrong in regards to Winter Sidhe. According to her, Harry was completely justified.

We [or at least, I am not] aren't talking about Mab's morality, we are talking about Harry's.  As an outside viewer, I judge Harry's actions on the basis of \my\ morality.  Consequently, I find many of his actions to be morally questionable.  This action of killing the one sidhe isn't the most reprehensible thing Harry has done.  But, Harry's slide into immorality isn't going to begin with Harry slaughtering mortals; it will begin with how he mistreats non-mortals.

Also, in order for something to be morally wrong there must be an absolute objective standard that makes it wrong.

There are quite a few different versions of morals where one doesn't need an absolute objective standard. Moral relativism is more in line with my thinking of morality.

Descriptive moral relativism is merely the positive or descriptive position that there exist, in fact, fundamental disagreements about the right course of action even when the same facts hold true and the same consequences seem likely to arise.[2] It is the observation that different cultures have different moral standards.

From a moral perspective killing is "always" wrong, so even the first one was morally questionable.

Not true.  This largely depends on whose morality we are talking about.

Ah, sorry raidem, but we are talking about murder.  Murder is a legal term, not a moral one.

And in the view of Winter, Mab doesn't consider murder to be a crime.  She has two laws: neither of which prohibits murder.  Her law is such that one may not speak to her without first obtaining permission and secondly, one must not draw blood. 

And, there is no real life law that makes killing sidhe a crime.  For one, sidhe don't exist in our world. Also, there is no equating killing of an animal other than human to be a crime of murder.

Murder: the unlawful premeditated killing of one human being by another.

  Morality is that which shapes what is lawful and what isn't.

Did you see the link that I included to where I talked about it under the "apprentices" thread.

We aren't arguing that Harry committed a crime.  We are arguing that from a human morality viewpoint, what he did was wrong.  Harry is all concerned about himself going bad.  It will start with him abusing the sidhe and then from there get worse. 

I have wondered if perhaps Harry's instructions to Cat Sith or Harry's new rule led to Cat Sith being susceptible to a mortal who infects him.